trio awarded nobel prize for cool method
Thursday 12 June 2025
Last Updated : GMT 09:40:38
Themuslimchronicle, themuslimchronicle

to study molecules

Trio awarded Nobel prize for 'cool' method

Themuslimchronicle, themuslimchronicle

Themuslimchronicle, themuslimchronicleTrio awarded Nobel prize for 'cool' method

British molecular biologist Richard Henderson
Stockholmsource - Muslimchronicle

A revolutionary technique dubbed cryo-electron microscopy, which has peered closer at the Zika virus and an Alzheimer's enzyme, earned scientists Jacques Dubochet, Joachim Frank and Richard Henderson the Nobel Chemistry Prize on Wednesday.

Thanks to the international team's "cool method", which uses electron beams to examine the tiniest structures of cells, "researchers can now freeze biomolecules mid-movement and visualise processes they have never previously seen," the Nobel chemistry committee said.

This has been "decisive for both the basic understanding of life's chemistry and for the development of pharmaceuticals," it added.

The ultra-sensitive imaging method allows molecules to be flash-frozen and studied in their natural form, without the need for dyes.

It has laid bare never-before-seen details of the tiny protein machines that run all cells.

"When researchers began to suspect that the Zika virus was causing the epidemic of brain-damaged newborns in Brazil, they turned to cryo-EM (electron microscopy) to visualise the virus," the committee said.

Frank, a 77-year-old German-born American, was woken from his sleep when the committee announced the prize in Stockholm.

"There are so many other discoveries every day, I was in a way speechless," said Frank, a biochemistry professor at Columbia University in New York. "It's wonderful news."

In the first half of the 20th century, biomolecules -– proteins, DNA and RNA –- were terra incognita on the map of biochemistry.

Because the powerful electron beam destroys biological material, electron microscopes were long thought to be useful only to study dead matter.

- Tea party -

But Henderson, a 72-year-old Brit, used an electron microscope in 1990 to generate a three-dimensional image of a protein at atomic resolution, a groundbreaking discovery which proved the technology's potential.

Frank then made it widely usable by developing a method between 1975 and 1986 to transform the electron microscope's fuzzy two-dimensional images into sharp, 3-D composites.

Swiss national Dubochet, added water.

Now 75, he discovered in the 1980s how to cool water so quickly that it solidifies in liquid form around a biological sample, allowing the molecules to retain their natural shape.

The electron microscope's every nut and bolt has been optimised since these discoveries.

The required atomic resolution was reached in 2013, and researchers "can now routinely produce three-dimensional structures of biomolecules," according to the Nobel committee.

"A scientific prize is an ambiguous thing, it highlights an individual when we should highlight a collective effort, but I'm not alone," Dubochet told a news conference in Lausanne after the award announcement.

The honorary biophysics professor was noted not only for his humility, but also his humour.

On his resume, Dubochet notes he was "conceived by optimistic parents" in 1941, and quips that suffering from dyslexia permitted him to be "bad at everything".

The trio will share the prize money of nine million Swedish kronor (around $1.1 million or 943,100 euros).

"Normally what I'd do if I was in Cambridge, we will have a party around tea-time in the lab but I expect we'll have it tomorrow instead," said Henderson, who works at the MRC Laboratory of Molecular Biology.

- 'Resolution revolution' -

The announcement was praised by the scientific community and observers around the world.

John Savill, professor and CEO at the UK government-funded Medical Research Council, said electron microscopy has enabled scientists to examine disease molecules up close.

It was used, for example, to compile a detailed identikit of an enzyme implicated in Alzheimer's.

"Determining the structure of proteins in humans is critical to understanding how they interact in the body and developing better drugs for diseases," Savill said in a statement.

Dave Stuart, structural biology professor at Oxford University, described the technique as a "resolution revolution" which has enabled researchers "to see in exquisite detail the structures of life".

It can also be used to examine proteins that kickstart the immune system's attack on intruder viruses.

For John Hardy, a neuroscience professor at University College London, cryo-electron microscopy "opens up the possibility of rational drug design".

"And as a biologist, I can say that the pictures are beautiful," he added.

The Nobel Literature Prize is to be announced on Thursday at 1100 GMT.

source: AFP

themuslimchronicle
themuslimchronicle

GMT 09:53 2018 Monday ,22 January

Hindi Diwas celebrations at Bhavans Kuwait

GMT 14:02 2018 Saturday ,13 January

IGCF to Debate Impact of Digital Age

GMT 10:03 2018 Wednesday ,10 January

Nose spray tested to kick gambling habit

GMT 07:52 2018 Tuesday ,09 January

Kindergarten Sports Day at ILOA

GMT 09:10 2018 Thursday ,04 January

Mouse study shows how alcohol may cause cancer

GMT 09:22 2017 Friday ,29 December

Self-healing glass: a cracking discovery

GMT 11:48 2017 Thursday ,21 December

SIS K-Tots make memories on picnic

GMT 09:34 2017 Wednesday ,20 December

Alaskan snow more than doubles due
Themuslimchronicle, themuslimchronicle
Themuslimchronicle, themuslimchronicle

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

trio awarded nobel prize for cool method trio awarded nobel prize for cool method

 



Themuslimchronicle, themuslimchronicle

GMT 08:28 2018 Saturday ,20 January

Egypt's President Sisi says will stand for re-election

GMT 05:58 2017 Saturday ,25 February

US new home sales rise in January

GMT 08:50 2016 Tuesday ,22 November

Withdraws controversial conviction bill

GMT 07:10 2018 Tuesday ,16 January

Hall of Famer Rodman arrested

GMT 11:50 2011 Saturday ,04 June

Baby girl killed in car crash on Palm Island

GMT 07:34 2018 Sunday ,07 January

Spain king pays homage to father Juan Carlos

GMT 14:20 2016 Thursday ,22 September

At the International Literature Berlin

GMT 22:03 2017 Thursday ,13 July

Ayman Zabib sad for his mother’s death

GMT 09:50 2017 Thursday ,02 November

A mixed picture for US cars sales

GMT 04:57 2017 Sunday ,03 December

Trump again insists 'no collusion' with Russia

GMT 15:25 2013 Monday ,15 April

Army bases in Damascus become prisons

GMT 18:00 2013 Monday ,03 June

New French school in Doha

GMT 16:50 2017 Sunday ,23 April

Tunisian gangs store quantities of expired food

GMT 14:06 2016 Tuesday ,11 October

Russia ready to join OPEC crude production curbs

GMT 15:47 2011 Wednesday ,03 August

Striking Chinese taxi drivers back at work
Themuslimchronicle, themuslimchronicle
Themuslimchronicle, themuslimchronicle
 
 Themuslimchronicle Facebook,themuslimchronicle facebook  Themuslimchronicle Twitter,themuslimchronicle twitter Themuslimchronicle Rss,themuslimchronicle rss  Themuslimchronicle Youtube,themuslimchronicle youtube  Themuslimchronicle Youtube,themuslimchronicle youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2025 ©

muslimchronicle muslimchronicle muslimchronicle muslimchronicle
themuslimchronicle themuslimchronicle themuslimchronicle
themuslimchronicle
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
themuslimchronicle, themuslimchronicle, themuslimchronicle